Systemic Lupus Erythematosus
About the Disease
Systemic Lupus Erythematosus, also known as lupus nephritis, is related to lupus erythematosus and autoimmune disease, and has symptoms including exanthema, pruritus and lupus-like rash. An important gene associated with Systemic Lupus Erythematosus is TREX1 (Three Prime Repair Exonuclease 1), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, bone marrow and skin, and related phenotypes are lupus nephritis and arthritis
Common Targets
G10666 | G7184 | G813 | G8459 | G26059 | G100302182 | G911 | G105379395 | G106480429 | G11040 | G1388 | G805 | G149233 | G7292 | G2885 | G574508 | G3606 | G7422 | G55930 | G959 | G115004 | G432 | G102 | G930 | G3107 | Asialoglycoprotein Receptor (ASGPR) (nonspecified subtype) | G3812 | G3821 | G1773 | G150223 | G2220 | G4938 | G87178 | G8864 | G51284 | G90199 | G5777 | G3604 | G3684 | G3813 | G23254 | G238 | G5294 | G8771 | G114548 | P16683 | G3656 | G643 | G3718 | G55892 | G7006 | G2213 | G23533 | G5478 | G948 | Interferon-alpha (IFN-alpha) (nonspecified subtype) | G5820 | G3716 | G6654 | G2826 | G7100 | G4353 | G4982 | G50616 | G100506211 | G5634 | G3119 | G7515 | G5144 | G84418 | G5337 | G29851 | G3397 | Glucosidase (nonspecified subtype) | G6696 | G90865 | G596 | G353143 | G10346 | G114788 | G6714 | G972 | G151306 | G1776 | G84465 | G3791 | G51185 | G919 | G944 | G6097 | G4240 | G7706 | G8718 | G11240 | G1894 | G5771 | G54809 | G54899 | G353144 | G441374 | G2597 | G57558 | CDK4/Cyclin D1 | G629 | G1012 | G2859 | G7186 | G23569 | G8379 | G2936 | G3456 | P5683 | G6672 | G23324 | G814 | G284395 | G9945 | G51311 | G5338 | G10892 | G1130 | G1956 | G4261 | G51561 | G91937 | G3845 | G728392 | G25 | G54715 | G29943 | G306 | Interleukin 17 (nonspecified subtype) | G23534 | G3447 | G7098 | G716 | G23439 | G5163 | G89870 | G55626 | G2969 | G3134 | G57661 | G3593 | G3717 | G84141 | G923 | G105370819 | G3553 | G7133 | G3738 | G389376 | G1026 | G5609 | G11052 | G4192 | G2237 | G2707 | G10042 | G3109 | G349408 | G50619 | G55106 | G2937 | G9750 | G79758 | G285962 | G2872 | G10535 | G9687 | G9910 | G51131 | G120892 | G6580 | G2902 | G91543 | G9354 | G5698 | Tyrosine-Protein Kinases Src (nonspecified subtype) | G100137047 | G169792 | G4060 | G197322 | G100873065 | G9056 | G129607 | G6774 | G2693 | P5684 | G3557 | Interleukin-1 (nonspecified subtype) | G808 | G10866 | G3848 | G79932 | G8741 | G55869 | G339789 | G1445 | G4842 | G220064 | G4791 | G22880 | G282617 | G4074 | G5142 | G100422877 | G55501 | G3242 | G3551 | G128826 | G6628 | G7015 | G4939 | G105 | G10745 | G10964 | G119 | G3569 | G132320 | G677 | G7172 | G2217 | G23294 | G83666 | G10013 | G5582 | G1503 | Phosphodiesterase IV (PDE4) (nonspecified subtype) | G4724 | G50856 | G286442 | G5914 | G4061 | G91351 | G3660 | G1675 | G7976 | G59272 | G152831 | G56649 | G9873 | G375790 | G6632 | G4940 | G51191 | G10170 | G101929099 | G29949 | G3497 | G3752 | G1788 | G695 | G79001 | G109 | Heat shock protein 90 (nonspecified subtype) | G25780 | G727 | G100874048 | G54739 | G3120 | G1269 | G1520 | G399909 | G23085 | G23765 | G101927960 | G3959 | G85377 | G3429 | G1991 | G24138 | G595 | G5578 | G3562 | G399923 | G801 | G11213 | Folate Receptor (nonspecified subtype) | G375248 | G6874 | G187 | G2280 | G84433 | G29767 | G3661 | G51564 | G1475 | G4869 | G23043 | G3559 | G6352 | G4049 | G219578 | G5077 | G84888 | G1233 | Matrix Metalloproteinase (MMP) (nonspecified subtype) | G7040 | G4893 | G10062 | G5610 | G4204 | G50628 | G1021 | G1111 | G578 | G2078 | G4439 | G4688 | G81844 | G5535 | G3117 | G4811 | G55182 | G10788 | G3932 | G79710 | G93974 | G4158 | G5359 | G8726 | G9474 | G660 | G9619 | G6717 | G440193 | G101929163 | Lipoxygenase (nonspecified subtype) | Phosphatidylinositol 3-kinase (PI3K) (nonspecified subtype) | G23359 | G57144 | G1326 | Protein kinase C (nonspecified subtype) | G254773 | G25825 | G6046 | G152002 | P6058 | G7099 | G7297 | G2201 | G9173 | G3112 | G57194 | G7189 | G415116 | G2152 | G5533 | G105377923 | G10673 | G3135 | G350 | G353500 | G8569 | G8698 | G9294 | G3336 | P12327 | G3566 | G3575 | G1436 | G145814 | G649 | G7332 | G80216 | G8743 | G54877 | G5133 | G525 | G64098 | G1959 | G55054 | G6868 | G9817 | G3297 | G122618 | G1723 | G23362 | G9020 | G3563 | G3783 | G728642 | G8600 | G929 | G962 | G6550 | P8262 | G2100 | G4780 | G91748 | G56244 | G57097 | G3156 | G9881 | G338707 | G3952 | G10320 | G942 | G114609 | G23187 | G4855 | G831 | G5291 | G1019 | G553128 | G3106 | G4277 | G29070 | G3118 | G11217 | G8519 | G285550 | G29126 | G129804 | G3815 | G714 | G4521 | G10066 | G3092 | P5614 | G383 | G10301 | G121260 | G26119 | G100128977 | G57674 | G3383 | G7852 | G5090 | G23547 | G613 | P33249 | G64753 | G3965 | G10131 | G286046 | G105378019 | G11274 | G1268 | G170482 | G6772 | G19 | G8260 | G5175 | G9235 | G2917 | G9620 | G331 | G6276 | G84159 | G4209 | G80736 | G105371388 | G115352 | G4137 | G22801 | G8269 | G8895 | G3123 | G1490 | G23476 | G100130476 | G5293 | G440275 | G7965 | G284459 | G155038 | G100 | G3600 | G1903 | G729230 | G406991 | G3595 | G6403 | G246778 | G57154 | G4690 | G2313 | G9145 | G3113 | G51466 | G1112 | G7535 | G53347 | G100049587 | G100287722 | G100379345 | G282973 | G10723 | G5467 | G3290 | G3312 | G221191 | G952 | G7514 | G51135 | G80739 | G27291 | G9071 | G958 | G1591 | G25989 | G933 | G3122 | P5833 | G84898 | G10005 | Pim Kinase (nonspecified subtype) | CDK6/Cyclin D1 | G3702 | G1803 | G7087 | G2289 | G23518 | G1314 | G231 | G3918 | G550643 | G143503 | G64754 | G6850 | G712 | G7442 | G581 | G135 | G282974 | G54790 | G11184 | G4046 | G4599 | G219790 | G5797 | G6786 | G1793 | G80314 | G5580 | G105371664 | G3605 | G3816 | G4316 | G84867 | G5551 | G64478 | G147746 | G7498 | G10365 | G2147 | G80231 | G23683 | G6229 | G3601 | G4170 | G728763 | G3065 | G5742 | G11102 | G5770 | G170679 | G2214 | G23057 | P16179 | G51702 | G26762 | G720 | G5054 | G51022 | G8036 | G5468 | G338328 | G5989 | G6304 | G636 | G646658 | G64805 | G221895 | G2842 | G55601 | G10561 | G330 | G57161 | G11074 | G120227 | G3567 | G7903 | G920 | G3434 | G4153 | G3732 | G102725019 | G9734 | Interferon (nonspecified subtype) | G170680 | G776 | G55191 | G57162 | P19878 | G23308 | G53831 | G8632 | G3663 | G1880 | G84166 | G285626 | G6504 | G7940 | G56262 | G4035 | G4860 | G79033 | G9378 | G105376397 | G3105 | G57292 | G6280 | G6387 | G285627 | G9891 | G1612 | G1997 | G7128 | G2952 | G7097 | G5335 | G931 | G6361 | G378938 | G8528 | G10724 | G474354 | G2475 | G101928354 | G9569 | G146850 | G4171 | G3480 | G3630 | G2570 | G10563 | G713 | G79960 | G2798 | G54923 | G112744 | G3802 | G896 | G9759 | G11031 | G114900 | G22806 | G6737 | G1310 | G401036 | G80018 | G25939 | G104384744 | G94240 | G57511 | G4322 | G55512 | G2913 | G9663 | G26137 | G54625 | G6482 | G3953 | G6775 | G2099 | G2678 | G55711 | G4121 | G23092 | G7092 | G23028 | G941 | G3704 | G6688 | G175 | G55915 | G3125 | G386679 | G79791 | G5888 | G23274 | G53637 | G115650 | G146923 | G4210 | G2358 | G836 | G916 | G64135 | G729085 | G81563 | G151888 | G84444 | G8491 | G1001 | G8638 | G9636 | G3467 | G611 | G6741 | G407021 | G200734 | G2194 | G4318 | G53840 | G100131814 | G9425 | G567 | G3454 | G4835 | G51752 | G5300 | G8808 | G8833 | G608 | G1969 | G83723 | G54887 | G10188 | G140688 | G3803 | Poly [ADP-ribose] polymerase (nonspecified subtype) | G101928376 | G101929755 | G2908 | P11025 | G640 | G23235 | G100505566 | G5579 | G115653 | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 (nonspecified protein) | G3705 | G23524 | G25802 | G54328 | G100996286 | G55917 | Janus Kinase (nonspecified subtype) | G51206 | G26010 | G53841 | G1027 | G554300 | G57169 | G3126 | G3552 | G3592 | G376412 | G3790 | G196 | G7093 | G7157 | G26191 | G284661 | G10410 | G6366 | G3665 | G4846 | G2638 | G1024 | G105374793 | G3064 | G3394 | Inosine 5'-monophosphate dehydrogenase (IMPDH) (nonspecified subtype) | G7148 | G5292 | G5444 | G6691 | G22807 | G285175 | G3304 | G114908 | G3437 | G6184 | G4602 | G2212 | G101928420 | G5696 | G9383 | G57586 | G6532 | G6857 | G101180976 | G105221694 | G22862 | G23136 | G5141 | G105376626 | G3558 | G356 | G728 | G55611 | G57514 | G59067 | P13475 | G220416 | G5532 | G192683 | G7077 | G7293 | G3269 | G101930748 | G9103 | G301 | G3579 | G55790 | P5758 | G51056 | G3292 | G201633 | G5534 | G5588 | G3115 | G1240 | G4067 | G407024 | G50604 | G8654 | G3804 | G186 | G440836 | G221491 | G105376748 | CDK6/Cyclin D3 | G144423 | G6890 | G26052 | G26150 | G3707 | G718 | G7850 | G974 | G11277 | G113730 | G100132285 | G10019 | G285848 | G5605 | G3054 | G347404 | G375612 | G3805 | G185 | G4313 | G81573 | G10318 | G6369 | G2314 | G284293 | G3075 | G3146 | G6556 | G177 | G10135 | G55243 | G146198 | P6884 | G406938 | G943 | G338 | G23007 | G53353 | G5423 | G105375013 | G339416 | G355 | G54106 | G101928512 | G3127 | G5743 | G57705 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3 (PDE3) (nonspecified subtype) | G3806 | G7421 | Ras GTPase (nonspecified subtype) | G393 | G407025 | G2215 | G4843 | G10665 | G11128 | G11167 | G222659 | G2625 | G684 | G9478 | G3458 | G3654 | G3808 | G3116 | G11103 | G8411 | G54839 | G2205 | G55666 | G55773 | G63940 | P44516 | G196074 | G105375015 | G940 | G107986092 | G5909 | G1756 | G710 | G85441 | G91833 | G29110 | G10758 | G140710 | G1493 | G4068 | G3423 | P36529 | G4282 | G254048 | G5290 | G89849 | G10257 | G375057 | G1608 | G2064 | G2581 | G100505894 | G10379 | G10939 | G340061 | G1234 | G55340 | G64115 | G1594 | G3956 | G124626 | G135644 | G8737 | G9641 | G23495 | G5781 | G59340 | G1901 | G51611 | G2944 | G946 | G6546 | G3809 | Peptidyl arginine deiminase (PAD) (nonspecified subtype) | G7294 | G5788 | P5681 | G6891 | P16740 | G6311 | G23387 | G10645 | G127623 | G1719 | G7124 | G79446 | G5150 | G100507436 | G91050 | G3810 | G4147 | G2063 | G5156 | G102465531 | G92799 | G3570 | G6531 | G4524 | G921 | P11049 | G352962 | G3586 | G7428 | G2322 | G105379185 | G85445 | G91056 | G3455 | G3565 | G387 | G85329 | G55024 | G3382 | G3811 | G50615 | G100506023 | P13024 | G795 | G1380 | G100133669 | G100302174 | G5538 | G103 | G152485 | G653361 | G2113 | G717 | G8618 | G100852410 | G2904 | G401250 | G50485 | G23586 | G54806 | G9290 | G84875
The "Target / Biomarker Review Report" is a comprehensive and customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about the Target(s) / Biomarker(s) of your choice related to Systemic Lupus Erythematosus, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
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